Recently Jameson et al. [ 75] suggested that the nonenzymatic functions of AChE splice variants are a target for the developmental neurotoxicity of organophosphates.
In the present study, we explored the corresponding effects in the developing nervous system to evaluate the potential contribution of nonenzymatic function of AChE splice variants as a target for the developmental neurotoxicity of OPs.
These results indicate that signal transduction through the AC cascade is a target for CPF during a discrete developmental period in late gestation, an effect that is likely to contribute to the noncholinergic component of CPF's developmental neurotoxicity.
The hedgehog (Hh) signaling pathway is a developmental signaling pathway that has been implicated as a target for anti-cancer drug development in a variety of human malignancies.
Make a target for yourself.
The presence of morphologically different flower types within a single genotype makes gerbera a unique target for reproductive developmental studies, since the traditional eudicot model plants (Arabidopsis, Antirrhinum and Petunia) bear only single flower forms in their inflorescences.
These findings have important implications for the role of these proteins in controlling development, suggesting that they are targets for developmental signals to regulate gene expression.
This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1 ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis.
Recently, neurotrophic factors and/or their signal transduction pathways have been reported as a potential relevant target for the developmental neurotoxicity of ethanol.
This finding frames the hypothesis that vascularization of the embryo placenta is a common biological target for the developmental toxicity of some environmental chemicals that act as pVDCs.
