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Amyloid ion channels with defined gating and pharmacological agents would provide a tangible target for designing therapeutics for AD pathology.
A tangible target that is not a trophy loses its charm, provoking a sense of anticlimax and a lack of competitive tension.
"It's very, very difficult to take little pockets of Muslims around the world who individually comprise small numbers but may well espouse violence - and they are few and far between - and make them a tangible target from the CIA's point of view.
And there was no better whipping boy for this than the mainstream press, for they represented, according to our theory, a tangible target for our disdain.
If they do, new hippocampal neurons may serve as a marker of risk for depression and provide a tangible target for developing more effective and tolerable antidepressants.
As an NTD, this should be a tangible target [ 74, 87].
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The evolution of proteomics over the past decade has seen it mature from its nebulous and esoteric origins into a facet of science with a tangible objective; to develop and apply targeted mass spectrometric assays for the analysis of human proteins [1].
The other thing that helps is a very tangible target.
The nemesis tweet is an act of aggression with no tangible target, like a wild punch at the air while envisioning your enemy's face.
Furthermore, in vitro and in vivo proof of concept studies validating the GCH1 GFRP axis as a tangible drug target to regulate endothelial BH4 are also lacking.
Several anti-cancer drugs have been shown to increase the expression of FOXO3a, which suggest it is a tangible therapeutic target for breast cancer therapy [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com