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The specific aims are: Aim 1: To examine the effectiveness of a tailored activity pacing intervention on fatigue, pain, and physical function.
In a pilot study, we found that participants who underwent a tailored activity pacing intervention had reduced fatigue interference with daily activities.
The overall goal of the study is to examine the effectiveness of a tailored activity pacing intervention for adults with symptomatic knee or hip OA.
At 10 weeks and 6 months post baseline, we will examine the effectiveness of a tailored activity pacing intervention on fatigue, pain, and physical function compared to general activity pacing and usual care groups.
This paper provides a description of our methods and rationale for a trial that evaluates a tailored activity pacing intervention led by occupational therapists for adults with knee and hip OA.
To examine the effectiveness of a tailored activity pacing intervention on fatigue, pain, and physical function, we will use repeated measures analysis of variance (RM ANOVA) models to analyze the responses (pain, fatigue, and 6 minute walk test) at baseline, 10 weeks, and 6 months for the three treatment groups (tailored activity pacing, general activity pacing, and usual care group).
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The major needs emerged in the case investigated are for an increase of actors' expectations towards the further development of the sector, and a need for a tailored networking activity, devoted to attracting specific knowledgeable actors.
The observed exceptional adsorption mode is of general relevance for functionalizing nanocrystal facets with molecular agents that require the stabilization of a particular ionic state for a tailored catalytic activity.
RNAi as an anti-viral therapy currently receives much interest, and synthetic siRNAs with tailored activity against HIV, hepatitis B virus, human metapneumovirus and RSV are under development [ 24, 43- 45].
Given the positive effects of the tailored activity pacing approach compared to general activity pacing on fatigue in a small pilot study, we hypothesize that fatigue in particular will be improved with the tailored activity pacing intervention.
Aim 3: To evaluate the effect of tailored activity pacing on physical activity.
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