Meanwhile, proteomics presents an effective approach to pursue a systems-based perspective of how proteins change, and thus how organisms adapt to various abiotic environments14.
Some business leaders have adopted a systems-based perspective, called the learning organization (LO), to address a similar dilemma.
While it is impossible to know what such a world would finally look like, he noted that it would be marked by a biological, systems-based view, a significant change from the more linear command and control systems that created the Industrial Revolution.
According to Ramsey et al, a more systems-based view on multifactorial disorders, where disease progression requires the coordination of several cell types, organs, and organ systems at various molecular levels, will contribute to a better understanding of disease aetiology [ 32].
The Community Health Centre sector, through many of their QI activities, used a systems-based and patient-centred view of QI-PHC, manifested using workshops, plain-language summaries and stakeholder engagement as part of their QI activities.
In their view, a systems-based deciphering of a living organism needs insight into its structure gene interactions, biochemical pathways, mechanisms by which they arrange cellular properties and intercellular interactions its dynamics, how it behaves over time and its controlling mechanisms, its design.
Because the effects of many cancer therapeutics are systemic, employing a systems-based approach would efficiently facilitate circulating biomarker discovery in ACIC.
Some adopt a systems-based approach (the cardiovascular system, the nervous system etc); others a problem-based approach.
A "systems-based candidate-gene" approach based on NetKO could provide a powerful approach to apply "a posteriori" biological knowledge to study the role of epistasis in disease.
A systems-based dissection of retinal inputs to the zebrafish tectum reveals different rules for different functional classes during development.
Parkinson's disease is a devastating neurodegenerative disease well suited to a systems-based microarray analysis.
