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The phrase "a systemic disease" is correct and usable in written English.
It can be used to describe a disease that affects the entire body or multiple organ systems rather than being localized to one area.
Example: "Diabetes is considered a systemic disease because it can impact various organs and systems throughout the body."
Alternatives: "a widespread illness" or "a global disease".
Exact(59)
Pythiosis can also be a systemic disease involving the vascular system, which usually causes arterial occlusion.
APS is now thought to be a systemic disease, affecting multiple organs and systems [ 2].
Diabetes is a systemic disease that can impact multiple organ systems, including the central and peripheral nervous systems.
Brucellosis is a systemic disease and may involve any organ system.
Alcohol use disorder is a systemic disease that affects all organs and systems.
COPD is a systemic disease that affects beyond the respiratory, cardiovascular and muscular systems.
"We were saying that atherosclerosis is a systemic disease.
The osteoporosis is a systemic disease of multicausal etiopathogenesis.
"You're still dealing with a systemic disease," said Dr. Karl Karsch, chief of cardiology at Bristol University in England.
Lymph node-positive bladder cancer is a systemic disease in the majority of patients.
Moreover, accumulating evidence suggests that ALS is possibly a systemic disease.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com