Sentence examples for a systemic application from inspiring English sources

Discrepancies were shown by means of a systemic application of the mentioned standards to a specially instrumented prototype of professional oven.

Despite these promising results, the tumour-suppressive functions of RAGE that were observed in specific tissues raise concerns against the therapeutic use of RAGE inhibitors and hamper a systemic application of such.

A systemic application of EMCV could be an option for metastatic CCRCC patients with infaust prognosis who cannot be treated surgically and do not respond to other conventional treatment options.

Unlike in systemic genetic disorders where one might want to transfect a majority of target cells of an individual by a systemic application of a gene formula, in the case of tissue repair or regeneration only a local effect is required and desired.

A brief (1 h), systemic application of a high dose of the ultra-short acting MOR agonist remifentanil reverses LTP induced by low- or high-frequency conditioning stimulation of C-fibre afferents or by subcutaneous capsaicin [ 36 ].

The experiments demonstrate that the lipoplex formulation OO4 DOPE 1:3 (n:n) at N/P 4 is a promising candidate for systemic application because of the high colloidal stability in serum without PEGylated lipids, high transfection efficiency, superior resistance against nucleases, reproducible complexation independent of ionic effects, and haemocompatibility.

It is probably the best candidate of a death ligand for systemic application because preclinical studies revealed that, in contrast to TNF and CD95 agonists, the application of trimeric, soluble TRAIL is well tolerated.

In a similar experiment a comparison of targeted and systemic application of IL10 was performed.

Temporal control of transgene expression can be achieved in several ways, but one of the most convenient methods is using constructs in which the GAL4 DNA binding domain is fused to a progesterone receptor transcriptional activation domain, and is therefore only activated by systemic application of a progesterone-receptor ligand.

10, 11 Therefore, an effective delivery system has to be designed to develop an injectable dosage form for systemic application.

In-vivo, the occurrence of up-states in the PFC is synchronous with activity in the VTA [60] and stimulation of the VTA can induce up-states in the PFC, and their duration can be significantly shortened through systemic application of a D1 antagonist [61].