The phrase "a systematic modification" is correct and usable in written English.
It can be used when referring to a deliberate and organized change or adjustment made to a system, process, or structure.
Example: "The researchers implemented a systematic modification to the experimental design to improve the accuracy of the results."
Alternatives: "an organized change" or "a structured adjustment".
We have followed a systematic modification of both the precursor concentration as well as the number of electropolymerization cycles in order to optimize the response of the films as hole selective contacts for organic photoelectrochemical cells.
As part of our search to identify dual targeting ligands for these receptors, we have carried out a systematic modification of a selective 5HT7 receptor ligand culminating in the identification of several dual 5-HT1A and 5-HT7 receptor ligands.
A systematic modification program examining various substituents at the 3-, 4-, and 5-positions on the thiazole ring afforded compounds with enhanced anti-HIV-1 and reverse transcriptase (RT) inhibitory activities.
This involved a systematic modification of the structure of amino alcohols by an appropriate placement of substituent functional groups, especially the hydroxyl function, relative to the position of the amino group.
Since novobiocin promotes client protein degradation at concentrations that also induce an HSR (Marcu et al., 2000a, 2000b; Figure 1A), a systematic modification of novobiocin was undertaken to identify structure activity relationships that yielded high-affinity C-terminal analogues that diverged client protein degradation from Hsp70 induction (Burlison et al., 2006; Donnelly et al., 2008).
This balanced, evolutionary-controlled variation of parameters which are responsible for generation of APs is advantageous as compared to a possibility of systematic modification of the parameters in computer simulations.
In his research and his voluminous writings, including "Walden Two" and "Beyond Freedom and Dignity," Dr. Skinner advanced the belief that individuals could understand themselves and build a better world only through systematic modification of their behavior according to scientific principles he promulgated.
Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure activity relationship (SAR) analysis through systematic modification of the 5-deazaflavin template.
The results open the possibility for a systematic anodic modification of the conducting polymer through organic electrochemistry in the solid state.
We identified 27e (TasP0428980) as a potent dual orexin receptor antagonist through the systematic modification of our original designed lead A. We demonstrated the potent sleep-promoting effects of 27e at ip dose of 3 mg/kg in a rat polysomnogram study.
By utilizing fluorescent reporters integrated into the same locus, for different signaling sentinels, we eliminate position effects and allow systematic modification of response elements in a constant genomic location.
