Four decades ago, the rise of hormonal therapy, such as tamoxifen for breast cancer, has remarkably enhanced tissue selectivity and thereby diminished adverse systematic events [ 3].
It is much more difficult to understand why, in the case of the Irx genes, there would have been systematic events leading to cluster maintenance after numerous instances of gene duplications, unless postulating some particular properties of the Irx genomic region that would, by itself, favor the conservation of the physical link between the duplicated genes.
We also found that a systematic choice of event costs (e.g. using costscape) can cover a substantial portion of the solution space.
Probabilistic uncertainties are highly structured in the sense that the probability function imposes a systematic ordering of events.
We performed a systematic search for such events and identified events that could be completely explained by 2 SNPs (n = 37), 3 SNPs (n = 17), and 4 SNPs (n = 1).
For this initial event a systematic deterministic analysis under the assumption of a single independent failure in one of the safety systems has been prepared.
During an anthrax event, a systematic approach to capturing data related to anthrax exposure and infection in P/PP/L women should be a high priority and should include reporting of obstetric and neonatal outcomes after infection and after prophylaxis with vaccine, antimicrobial drugs, and antitoxin.
Considering the possible AS effect on 'regulation'-related genes, we conducted a systematic survey of AS events that occurred in genes encoding TFs.
They are: the need for a systematic approach to identifying events that could lead to accidents; robust measures to prevent those events progressing this far; and effective periodic review of safety analyses, to make sure they continue to meet high and continuously evolving regulatory standards.
On the other hand, it is likely that exocytic and endocytic events are occurring at the active zone in adjacent sections, leading to a systematic undercounting of recycling events per synapse.
