The thoughtful design of new clinical trials of A2A antagonists should take into consideration these counterbalancing hopes and concerns and may do well to shift toward a broader set of disease-modifying as well as symptomatic indications in early PD.
The symptomatic indications included disabling back pain that resulted in lifestyle alterations and failure of nonoperative treatment for more than 6 months.
Willow bark preparations, better tolerated by patients than synthetic derivatives, can be used for the traditional symptomatic indications of fever, infections, mild rheumatic complaints, headache, and chronic pain syndromes and extracts of bark have antioxidant abilities, thus many people have begun to turn back to willow bark as an alternative to aspirin [ 18– 22].
A pancreatic cyst in a symptomatic patient is an indication for cytological evaluation, and/or for drainage, with different methods being available depending on cyst etiology, size, and other variables [ 14, 15].
The indication for surgical repair of a symptomatic rotator cuff tear depends on the size of the tear, the condition of the muscles, and the age and activity level of the patient.
9 This indication is obvious in patients with a symptomatic primary.
The indication of palliative resection prior to initiation of systemic treatment in patients with a symptomatic primary tumour is obvious.
A symptomatic full-thickness cartilage lesion (Outerbridge grade III or IV) or an osteochondral lesion (2 12 cm2) was considered an indication for ACI.
In a symptomatic chronic injury.
Current guidelines consider aortic valve replacement as a class I indication for symptomatic patients [ 2, 3], facing, however, the fact that one-third of patients are considered to have an unacceptably high risk for open surgery [ 4].
Protonix received a labeling claim of "complete relief of daytime and nighttime heartburn and the absence of regurgitation" based on the patient daily diary as well as an indication of "symptomatic relief".
