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In addition to this rapid effect, we also detected a sustained activation of ERK1/2 and a sustained increase of p21 (Fig. 5B, C).
A sustained reduction in EDSS score of > 1 point was observed in fifteen patients (5.2%) and a sustained increase of > 1 point in three patients (1%).
Furthermore, a severe perturbation of the calcium (Ca2+) homeostasis and a sustained increase of the Ca2+ resting level in response to PAF exposure are directly connected with PAF toxicity in Neurospora crassa [8,9].
Obesity is a result of imbalance between energy intake (EI) and energy expenditure (EE) and a sustained increase of the EI not matching the EE, will lead to increased fat deposition and body weight (BW) gain.
The other type of abnormal response is postural orthostatic tachycardia, which consists of a sustained increase of heart rate of at least 30 beats per minute or a sustained pulse rate of 120 beats per minute.
Denosumab have been shown to produce a sustained increase of bone mineral density over 8 years of treatment, and to reduce the risk of new fragility fracture up to 5 years of continuous treatment.
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Figure 2 illustrates a large, sustained increase of ILI beginning December 12 , 2000
Goethite has a strong affinity for carboxylic C and select polysaccharide-associated functional groups at low initial C Fe molar ratios (Fig. 2c), whereas HMO has a sustained increase in sorption of polysaccharide-associated C over a wider range of initial C metal molar ratio (Fig. 1c).
The injection of mustard oil (MO) into the TMJ produces an acute inflammatory response in the tissues and a sustained increase in the excitability of the nociceptive brain-stem neurons of the subnucleus caudalis of the V cranial nerve, with activation of the jaw opening and closing reflex [ 24].
Exposure of p53wt Mel-29 cells to p28 produced a sustained increase in the level of TOPORS that was not transcription dependent, whereas exposure of p53mut Mel-23 cells to p28 reduced the level of TOPORS over 48 h, which was not preceded or accompanied by a change in transcription.
Moreover, 30% of hemp seed pill treated patients had a sustained increase in the frequency of completely spontaneous bowel movements.
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