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Polymorphisms amongst rat strains in these genes are associated with a susceptibility to developing a variety of autoimmune diseases in the rat which include type 1 diabetes, thyroditis, arthritis and autoimmune encephalomyelitis [33].
Elucidating the hereditary component has proven difficult because multiple genes seem to produce a susceptibility to developing endometriosis.
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This finding suggests that migraineurs bear a susceptibility to develop migraine attack after NTG administration as a specific trait linked to a supersensitivity of the pain system to NTG [28].
Any tissue sensitive to this altered transgenerational transcriptome will have a susceptibility to develop disease [ 23].
Another tentative explanation is that this mammographic pattern reveals a susceptibility to develop new in situ lesions.
South Asian and Chinese groups may have a greater susceptibility to developing diabetes due to a predisposition to insulin resistance in the presence of environmental factors including diet and physical inactivity.
Several scientists suspect that some people may have a genetic susceptibility to developing Crohn's possibly by drinking milk infected with MAP.The government and the industry both insist that pasteurisation heating up milk to a high temperature for a short period kills any MAP that gets into it.
Indeed, preliminary data from Acioli-Silva et al. [27] have suggested that individuals with a polymorphism that is associated with increased mRNA expression of factor H have a reduced susceptibility to developing DHF.
[24] Given the role of BIRC5 in the development of NPC, together with the earlier described functional relevance of -31C/G in modulation of BIRC5 expression, one might expect that individuals who carry the -31 CC genotypes, and thus have increased expression of BIRC5 and subsequently increased anti-apoptotic function, may be at a higher susceptibility to developing NPC.
Further, it is unclear whether these groups also have a greater susceptibility to developing complications of diabetes.
Therefore, these individuals have a "genetic susceptibility" to developing iron overload but may never do so, for reasons that are still to be determined.
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