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To explore the robustness of the primary analysis, a supportive analysis of period 1 alone was examined.
A supportive analysis of clinical efficacy data conducted in patients with centrally confirmed ER+ or PgR+ tumors also showed that outcomes were significantly improved with letrozole (n = 124) compared with tamoxifen (n = 126) [ 37].
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The FATF report acts as a useful corollary and counterpoint to a recent U.S. State Department report on terrorism around the world, which offered a broadly supportive analysis of Saudi efforts and emphasised the cooperation between Washington and Riyadh.
A supportive analysis, in the form of an ANCOVA that included a treatment by dose group (i.e. higher or lower dose) interaction, further confirmed non-inferiority of fluticasone/formoterol for this secondary parameter.
A supportive analysis will investigate any effect of time by including the fixed effect of year.
In the case where the primary non-inferiority endpoint was met, an additional supportive analysis of superiority of the primary endpoint was performed.
As a supportive analysis, a logistic multivariate model was applied on the composite endpoint for measuring the effect of CRT optimization frequency adjusted for the optimization method used.
The Per-Protocol (PP) population was used as a supportive analysis.
Non-parametric methods were also used on the primary efficacy variable as a supportive analysis.
The secondary, supportive analysis of PFS by independent oncology review showed an HR of 0.54 (95% CI, 0.39 0.76), i.e. a statistically significant 46% risk reduction of DP or death (P = 0.0002) with the trabectedin/PLD combination (Table 2).
A supportive multivariate analysis of ORR, adjusted for the same covariates as used for the TTP analysis, showed that prior adjuvant tamoxifen, as well as visceral or bone metastases as the dominant site of metastases, significantly decreased the probability of achieving a response.
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