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Nevertheless, in a combined analysis of the data from the same trial and a supplementary trial where metformin was given in combination with sulfonylureas, the effect of metformin on cardiovascular outcomes was not substantiated, due to increased cardiovascular mortality in the combination group (HR 1.96) (2).
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Studies within the program based on an Asian population were excluded, as were unpublished supplementary trials.
Otherwise, supplementary trials were proposed until two MVCs reproducible within 10% were obtained within a maximum of 5 trials.
First, both surveys included a detailed questionnaire, a supplementary questionnaire and a clinical trial.
The factorial design randomised controlled trial with a supplementary process evaluation using semi-structured interviews and usage-monitoring will collect preliminary evidence of efficacy, feasibility and acceptability, as well as feedback about the barriers and strategies to using such an innovative resource.
Where Cochrane data were not available we performed a supplementary search for placebo-controlled trials.
14 15 We conducted a randomised, investigator blinded controlled supplementary feeding trial in Malawi to test the hypothesis that among wasted adults with HIV starting antiretroviral therapy, patients who receive the fortified spread for 14 weeks will have a greater increase in BMI and fat-free body mass than those receiving corn-soy blend.
These few coincidences are rather equally distributed across the trials (as opposed to occurring in rapid succession within a trial) in both CC and UE periods as indicated by the high probability to observe exactly one coincidence in a given trial (Supplementary Fig. S2 A4 ) opposed to 2 or more coincidences.
These statements included clarity about explanations of randomisation, side effects of treatments and voluntary nature of a trial (see Supplementary online material 2).
Further, no differences between genotypes were observed in the FST in which the cKO and control mice spent equal time swimming in a two-day trial experiment (Supplementary Fig. 1A).
Medically low risk women, who participated in a randomized controlled trial of supplementary prenatal care between April 2001 and July 2004 and agreed to future research, were invited to participate in this follow-up study.
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