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In a smaller supplementary subset we repeated the analyses adjusting for current socioeconomic status of offspring, which had been assessed in a subset of the offspring born in 1950-55 according to the registrar general's classification of occupations with a six point scale ranging from unskilled, semiskilled manual, skilled manual, skilled non-manual, managerial to professional (fig 1).
In a supplementary analysis using a subset of our data, we compared the perception of novel scenes with the perception of scenes which had already been viewed for 8 s (Supplementary Figs 1 and 2 and Text 4).
A subset (supplementary table S6, Supplementary Material online) of sequences was used for the in-depth analysis of the POTRA sequences and phylogenetic tree inference; the barrel was defined as the sequence starting after the last POTRA until the C-terminus of the respective proteins.
Gene expression profiling showed that IMEC-WT and IMEC-MYC differ for the expression of a specific subset of genes (Supplementary Fig. 1f) whose regulations was not affected by global transcriptional amplification, as they showed equivalent total RNA/cell content and similar cell size (Supplementary Fig. 1g, h)29,30.
In this study, mutation screenings and methylation quantifications in Series B were carried out in matching normal samples from a subset of cases (Supplementary Table S1, see section on supplementary data given at the end of this article).
In contrast to the massively enlarged lysosomal structures observed in lrrk NS flies, lrrke03680 homozygous flies showed a mild increase in the size of the Rab7-positive late endosomal compartment in a subset of cells (supplementary material Fig. S2F) and no discernible change in lysosome morphology by Lysotracker staining (supplementary material Fig. S2I) (Dodson et al., 2012).
A ball plot of OR response profiles is shown in Figure 3e for a subset (see also Supplementary Figure S8).
38 such junctions were assembled (Supplementary file 4) and a random subset of 12/12 were confirmed by PCR followed by Sanger sequencing to demonstrate the accuracy of the de novo assembly.
To demonstrate the EBM's ability to stage patients using purely cross-sectional measures we repeated the patient staging by fitting the EBM for a subset of 12 events (Supplementary Tables 1 3 and Supplementary Figs 1 4), excluding atrophy rates.
We consider a subset (listed in Supplementary Table S1 online) of the diseases identifiable via the platform.
In addition to brain axon tract deficiencies, we demonstrated that pigmentation, indicative of neural crest lineages that include peripheral nerves (Schilling and Kimmel, 1994), was abnormal after LOF in a subset of homologs (supplementary material Fig. S3).
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