A supplementary study was conducted in order to study if the increased amount of anthocyanins was related to the gene expression of flavonoid pathway genes in bilberries (Additional file 1).
As a consequence of these discussions, some tails were removed and injuries were studied in more detail in a supplementary study [ 10].
However, there is an absence of definitive guidance regarding when to pursue supplementary studies, in part due to ill-defined criteria of what constitutes an adverse effect and to surgical/technical monitoring limitations of study designs.
In a second supplementary study 7 individuals were subjected to the same exercise program and sampling of blood was performed at fixed intervals before, immediately after, 30 and 60 minutes after the exercise session and then with 60 minutes interval for another five hours after exercise to monitor the short-term changes of serum COMP.
One group had all its supplementary study materials, in English, history and science courses, reset in an unusual font, like Monotype Corsiva.
In a supplementary small study we examined the short-term changes of serum-COMP immediately after exercise, study 2. In study 1 patients aged 36 65 years with symptomatic radiographically verified knee OA, uni- or bilateral Kellgren-Lawrence grade 3 or more, were included in a randomised controlled trial of physical exercise in knee OA.
Supplementary studies are conducted in certain instances either as a follow-up to the findings from this initial testing battery and/or to satisfy a regulatory requirement.
GeneScissors is able to distinguish expressed pseudogenes from the rest with a comparable accuracy, demonstrated by a simulation study in the supplementary material.
Numerical simulation provides a supplementary method to study the details in the micro-scale flow, which is difficult to be studied by experiments.
Finally, NPA scores could be used as a supplementary source of information in studying different types of mathematical models of regulatory networks.
