To protect against infection, D. melanogaster employs a suite of cellular and humoral defense mechanisms, making it a good reference organism in which to dissect host responses (reviewed in [1], [2], [3], [4], [5], [6]).
We therefore propose that the apical-growth gene expression signature defines a suite of cellular activities that, like the tip high calcium gradient, are required for the extension of tip growing cells.
Collectively, these experiments validated the TRIM24 AlphaScreen assay for chemical library screening [ 11, 14] and we embarked on developing a suite of cellular assays to follow-up on the HTS campaign.
Autophagy is a suite of cellular recycling processes in which macromolecules and organelles in the cell are degraded into raw materials that can then be used for the synthesis of new macromolecules.
Each PIP binds to a distinctive set of effector proteins and, thereby, regulates a characteristic suite of cellular processes, including membrane trafficking, cell survival/growth, cell division, and cellular motility [ 28] (See also Figure 5).
At the same time, a suite of genes representing cellular components were up-regulated, including some involved in B- and T-cell development.
Using a variety of GFP-based markers, we observed that cells abutting the wound site, or following treatment with benzonitriles, display a suite of dynamic morphological events that culminate in cellular contraction and cell death.
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ROS are generated during normal cellular metabolism and are detoxified by a suite of antioxidant enzymes including superoxide dismutases (SODs), catalases, glutathione (GSH) peroxidases, and thioredoxins (36− 38) as well as by dietary antioxidants (39).
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It is well known that Wnt/β-catenin pathway regulates the transcription of a suite of genes controlling numerous aspects of development and human diseases, ranging from cellular proliferation, differentiation and apoptosis [ 3, 4].
