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To establish a suitable significance threshold, we examined 59 known breast cancer regions with no known association with PrCa prior to this analysis.
Chromosomal regions harboring QTL affecting the trait mean are located by the highest values of the test statistic above a suitable significance threshold (e.g., B roman and S en 2009).
In a polygenic trait, there will be some inconsistencies in the sharing of founder alleles and hence a linear mixed model can be used to evaluate the maximum-likelihood estimate (derived LOD score) for each genomic position with a suitable significance threshold to differentiate signal from noise.
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Just on that account, however, a last hurdle remains: finding a suitable criterion of significance for theoretical terms that allows the distinction between analytic and synthetic statements to be drawn in the non-observational, theoretical languages of science.
Without a suitable comparison, its significance is easily over-interpreted.
Likewise, consensus structure prediction is also an ideal starting point for sRNA prediction; however, it has to be validated by a suitable measure of significance like thermodynamic stability.
In general, the rationale is to select some oligos from the input sequences, align them and score the resulting profile according to its conservation with a suitable measure of significance.
Variant or gene-by-environment interactions may occur among factors that fail to reach a suitable level of statistical significance association studies (p and q).
Data sets and derived ommatidial mis-patterning scores are readily assessed for significance using a suitable statistical test if an investigator's aim is to show a clear difference between two or more genotypes (e.g., Student T-test, found in most spreadsheet programs such as Microsoft Excel).
However, without a suitable methodology to specify the significance of these events, we may confuse alternative with specifically regulated polyadenylation.
Subcellular localization therefore presents a suitable criterion to assess the biological significance of the predicted associations in P. infestans independently of the initial benchmark of (homology-based) KEGG pathways used to derive the LLS for each association.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com