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A suitable motif for the new Labour leadership?
The porphyrin TMPyP4 was early reported to be a suitable motif for G-quadruplex DNA interaction.
The first method depends on ab initio motif searching based on the supposition that if there are cis-elements playing important roles in the regulation of a given set of genes, they will be statistically overrepresented in the associated promoter sequences as conserved motifs that can be identified by using a suitable motif search program.
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Quantitative analysis of the peak TF motif densities relative to chance expectation can delineate a suitable threshold for motif scores for a given PWM.
The lack of a well defined LexA-binding motif and/or more than one complete genome sequence within a given phylogenetic group restricted our analysis to the β-Proteobacteria, to which the here-validated LexA-binding motif can be applied [ 43] and to the α-Proteobacteria, in which a suitable LexA-binding motif has already been experimentally validated for comparative genomic approaches [ 64].
Discovering motifs in practice requires us to choose a suitable space of motifs to be searched.
Finally, the entire pattern is obtained by replicating the unit motif in a suitable net.
At either 'low level' or 'high level' of the network, the network motif is a suitable and essential building block or functional unit to characterize both relatively small elements, i.e. molecules, at a 'low level', and relatively large ones, i.e. modules, at a 'high level'.
However, it is not known if a para-triazole nitrogen (as is the case in analogue 35) provides a suitable atom to complete the recognition motif; this may explain why 35 is not actively transported.
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CEO of Professional Science Editing for Scientists @ prosciediting.com