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As well as the challenge of finding a suitable lead, Gilroy's main job will be to persuade audiences to see a Bourne film that neither features Matt Damon, who made the role famous, nor the protagonist Jason Bourne – the role that catapulted the actor to the head of the Hollywood A-list.
Thus, this class of compounds represents a suitable lead for enhancement of affinity through chemical synthesis.
Thus 11a could be a suitable lead towards the design of broad spectrum anti-tumor active agents targeting various human tumor cell lines.
Hence, 47 exhibits potent anti-cancer effects on HCC cell lines, and is a suitable lead for developing multi-targeted kinase inhibitors of relevance to HCC.
Therefore, compound 13 could be a suitable lead for further investigation and the development of selective HDAC 2 inhibitors as potent anti-cancer compounds.
Structural studies revealed that compound 20- R) is the most potent fluorinated-quinazolinone inhibitor of KSP and represents a suitable lead candidate for further studies on designing 18F-radiolabelled agents for positron-emission tomography (PET).
Similar(49)
But that fell through after a suitable male lead could not be found.
The identification of drug-like molecules from interacting peptide sequences in appropriate screening assays could lead to a significant extension of useful drug targets and the discovery of suitable lead compounds.
A number of safety tests are performed on animals, prior to clinical trials in humans, in order to select the most suitable lead chemical and dosage form for drug development.
Metabolites and NPs could potentially provide suitable lead molecules.
In particular, identification of suitable lead compounds is one of the key challenges in early drug discovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com