Antibodies against a variety of subtly modified glycans have been found in humans: for example, N-glycolylneuraminic acid, which differs from sialic acid by addition of a single hydroxyl group, acts as an antigen in humans, and a variety of sialic acid glycoengineering studies have found that other unnatural sialic acids are immunogenic as well.
This arrangement may serve to buffer ligand/receptor allelic polymorphism, thereby creating a reservoir of subtly modified interfaces upon which diversifying selection can act to efficiently identify IL4 variants that have lost the ability to interact with parasite-derived IL4-binding molecules.
The Hebrew texts in particular feature what have been called "key-words," words or phrases repeated and subtly modified in a passage, as a kind of threaded meaning.
JDM Legends, a garage based in Murray, Utah, has restorations ranging from the faithful to the subtly modified – the white Skyline GT-R coming with a twin-turbocharged RB26 engine swap from a late '80s Skyline.
The political system is based on the Westminster model inherited from Britain, but subtly modified to prevent the emergence of a serious opposition party.
In the above test when cutting and pasting from an HTML page into WordPad you'll notice that the accounts are subtly modified in each case while leaving the beginning of the address unchanged.
The advantage of such a piece is that spacing between letters, even the letter forms themselves, can be subtly modified.
Key roles for residues conserved between bacterial and eukaryotic homologues suggest a conserved mechanism of peptide recognition and transport that in some cases has been subtly modified in individual species.
The same tropes are bound to recur, subtly modified, as similar problems bring forth similar solutions.
This understanding was subtly modified by Thoreau's mentor, Emerson, who agreed that the world was a manifestation of spirit — "Every natural fact is a symbol of some spiritual fact," he wrote — but believed natural facts had only a latent meaning until they were perceived by a human observer.
Sumerian in origin, Mesopotamian religion was added to and subtly modified by the Akkadians (Semites who emigrated into Mesopotamia from the west at the end of the 4th millennium bce), whose own beliefs were in large measure assimilated to, and integrated with, those of their new environment.
