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By contrast, normotensive anemia (1 1 HES/blood fluid exchange) preserved global organ perfusion but was unable to prevent a subtle reduction in brain tissue PtO2.
For instance, a person's asthma will be deeper than his or her skin rash, a person's fear of death will be deeper than his or her irritability, and a person's loss of self esteem will be deeper than a subtle reduction in memory.
A subtle reduction in the recovery kinetics of SR45/U1-70K complex was observed with staurosporine (Figure 7).
Although only a subtle reduction in respiratory enzyme activity was detected in the whole pancreas at 26 weeks following nicotine exposure, this may represent a more profound change in the beta cells, which comprise approximately 1% of the adult rodent pancreas [14].
Nevertheless it still remains a formal possibility that in key neurons of the fly brain that control LTM, a large reduction in Notch could have a subtle reduction in CBP, and that this subtle reduction is responsible for the LTM phenotype that is observed.
There was a subtle reduction in CD127 expression postdepletion, which reverted after 21 days.
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In contrast, the D-loop-E mutation in the Smc1 ATPase active site (SpSmc3DE), analogous to the smc3-D1161E allele that abolished chromosomal association of cohesin, led to a subtler reduction in cohesin's total ATPase activity.
A subtle reduction of Pten in the Pten+/− mice appears sufficient to achieve a prolonged and robust insulin signal.
This also correlated with a more subtle reduction in H3K27me3 but largely unchanged levels of H3K4me3.
This spreads the reduction of glycerol yield not only over different target genes, each causing a subtle reduction, but also over different nodes in the cellular network and thus likely minimizes further the risk of negative side-effects.
Interestingly, in a recent report [ 50], it was shown that in mice with a subtle reduction of PTEN expression (80% of the normal level), different types of tumors developed with mammary carcinomas occurring at highest penetrance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com