Sentence examples for a subtle modification of from inspiring English sources

Our results clearly indicate that agonism and antagonism of the antibody/cytokine receptor chimera can be readily switched by a subtle modification of the ligand binding domain as well as that of GPCRs, also implying the existence of inverse agonism in cytokine receptor superfamily.

Some roles of the Tβ4 and Tβ10 couple are linked to a subtle modification of their relative amounts [11].

Low level fold-change acts in favor of a subtle modification of brain gene expression, much as has been suggested for task specialization [ 41].

Now a team reports that one serious side effect can be overcome by a subtle modification in the amino acid sequence of the promising drug.

Detailed structure-activity relationships (SARs) studies on the aglycone of compound 1 indicated that the subtle modification of oleanolic acid as an aglycon has key influences on the antiviral activity.

Detailed structure activity relationships (SARs) studies on the aglycone of compound 3 indicated that both the type of pentacyclic triterpene and the subtle modification of ursolic acid as an aglycon had key influences on the antiviral activity.

However, we mention it as an example of how this approach may highlight networks of proteins, where subtle modification of multiple partners may result in cumulative disruption that would lead to disease under a multiplicative burden of rare variants model.

In our cases, subtle modification of Fisher's method was introduced to improve lip contour on the philtral ridge; orbicularis oris muscle overlapping.

The action of antifungal agents is modulated by subtle modification of the membrane lipid composition [17].

This suggests that the subtle modification of physiological levels of endogenous miRNA leads to more significant and biologically indicative changes in target gene expression than the supra-physiological expression induced by synthetic miRNA.

The ability to identify important yet subtle modifications of lipid A is imperative for correlating immune responses with lipid A structures.