The phrase "a substrate upon which" is correct and usable in written English.
It can be used in scientific or technical contexts to describe a surface or material that serves as a base for a process or reaction.
Example: "The researchers applied a layer of polymer as a substrate upon which the chemical reactions could occur."
Alternatives: "a base for" or "a foundation for".
It is a substrate upon which calcium carbonate can be deposited by the outer surface of the outer mantle fold.
A 6 × 10 × 2 mm crystalline glass ceramic material (Sitall, Ukraine) [25] was used as a substrate upon which the interdigitated Ni electrodes were deposited by a thermal evaporation technique (Fig. 1).
The surface of the seamount also provides a substrate upon which organisms can attach themselves and grow.
Gene duplication in a genome provides a substrate upon which selection may act.
"These organisms live so intimately with each other, each one making a substrate upon which others live.
The final amplification step of the assay involves addition of a substrate upon which the enzyme (conjugated to the detector antibody) functions with a very high turnover rate to produce a detectable product.
Reef-building coral polyps (Scleractinia) are organisms of the phylum Cnidaria that create a calcareous substrate upon which a diverse array of organisms live.
It is clearly oversimplistic to view the serotonergic system as a homogeneous substrate upon which pharmacological agents act to produce monotonic changes in behavior.
On the other hand, since Raymond accepts a view according to which sex is a given, biological substrate upon which cultural role is assigned, identity may simply be taken to reflect recognition of one's own invariant biological sex (male or female).
Acute and prolonged responses may be homeostatic and provide for defense of the host, but if excessive in degree or duration may provide a chronic inflammatory substrate upon which such disorders as asthma and pulmonary fibrosis may ensue.
Inhibition, in enzymology, a phenomenon in which a compound, called an inhibitor, in most cases similar in structure to the substance (substrate) upon which an enzyme acts to form a product, interacts with the enzyme so that the resulting complex either cannot undergo the usual reaction or cannot form the usual product.
