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Respondent fatigue, particularly in the youngest cohort, was a concern although anecdotal evidence suggests that it was not a substantive problem.
Nevertheless, a substantive problem which is obstructing space development by humans, in particular flight to Mars, is the early readaptation period to gravity.
There is a second substantive problem with Australia's chosen World T20 bowling unit – the absence of an in-form, internationally proven death bowler.
A more substantive problem that needs to be addressed by the microarray community is the choice of an appropriate reference sample.
And until we solve that problem, I see little hope for substantial progress in solving just about any substantive problem faced by society.
To address the extent to which nosocomial MRSA and VRE are substantive problems in rural hospitals, we conducted a prospective study in rural Utah and Idaho.
There are substantive problems with both arguments.
In their response to him, he said "they treated it like a public relations problem, rather than a substantive issue for the business".
"They treated it like a public relations problem, rather than a substantive issue for the business," he said, in a statement that's just as relevant today as it was then.
In economics, the language of mathematics is sometimes necessary for representing substantive problems.
For instance, the efforts to limit a company's number of subsidiaries didn't address substantive problems, she said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com