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The phrase "a substantive portion" is correct and usable in written English.
It can be used when referring to a significant or meaningful part of something, often in legal, academic, or formal contexts.
Example: "The report highlighted a substantive portion of the data that was previously overlooked in the analysis."
Alternatives: "a significant part" or "a meaningful segment".
Exact(9)
An intermediate-sized plate of rosti topped with beef stroganoff was full of good flavours and, at £4.50, a substantive portion.
Jonas Lund has entrusted a substantive portion of his professional, personal, and artistic life to the owners of a currency he created using blockchain technology.
In order to evaluate our approach, we developed a new corpus, ImCor, which consists of a substantive portion of the Corel image data set associated with disambiguated text drawn from the SemCor corpus.
"Our brains have been trained to allot a substantive portion of our 'automatic attention' to our smartphones". Every time I use the phone for something indisputably meaningful, such as tending to a friendship, I'm reinforcing the allure of all its other functions, most of which aren't.
OBJECTIVE: To investigate whether the use of physician assistants (PAs) as providers for a substantive portion of a patient's office-based visits affects office visit resource use.
PRINCIPAL FINDINGS: After case-mix adjustment, patients for whom PAs provided a substantive portion of care used about 16percentt fewer office-based visits per year than patients cared for by physicians only.
Similar(51)
But Robin then adds a substantive component.
Believe it or not, that was the "substantive portion" of the show.
Mitch McConnell's appearance on the show indicates that the substantive portion of the hour is now over.
The substantive portion of the social gaps explained at ages 16, 30 and 42 indicate that living circumstances do indeed account for much of the socioeconomic inequalities in self-reported health in Sweden.
This is the first time substantive portions of the collection have gone on tour.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com