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The phrase "a substantive case study" is correct and usable in written English.
It can be used when referring to a detailed and significant examination of a particular instance or example within a research or analytical context.
Example: "The research paper presented a substantive case study on the effects of climate change on coastal communities."
Alternatives: "a significant case study" or "a meaningful case study".
Exact(1)
The application of the models to a substantive case study involving occupational health data, specifically medical tests for employees, demonstrated the complementarity of the analyses.
Similar(59)
An African American MBA graduate compared notes with her fellow classmates after interviews to learn that she was the only one being asked about diversity; her classmates, in contrast, received substantive case study questions.
"Predominantly my line is, if they are due to go before a board and it is a substantive case, they go before a board.
The most remarkable thing about the case is that this is the first in which this shadowy tribunal held a public hearing to consider a substantive case.
By dominating the screen and making a substantive case, Biden ultimately triumphed over his youthful co-star.
Republicans are dismissing the Democrats' complaints as simply picking a fight over process where they lack a substantive case to end the investigation.
Only one substantive case-control study of sporadic cryptosporidiosis in the immune-competent population has been conducted in an industrialized nation (6).
A case study from Flores, Indonesia provides evidence of a substantive, quantified economic benefit of watershed service based on a fixed-effects regression model of water collection costs.
Here's a minor case study.
Colonoscopies offer a compelling case study.
We therefore give a brief case study to demonstrate the potential of the present framework, but this is far from an exhaustive application of its usefulness for other substantive questions, nor is the case study described in complete rigor.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com