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The phrase "a substantive burden" is correct and usable in written English.
It can be used in legal or philosophical contexts to refer to a significant or meaningful load or obligation that affects a person or entity.
Example: "The court found that the new regulations imposed a substantive burden on small businesses, making compliance difficult."
Alternatives: "a significant burden" or "a meaningful burden".
Exact(2)
The SE Asian region also has a substantive burden of infectious disease such as HIV and malaria, which may modify associations between urbanization and development of NCDs.
NSCL/P patients are subjected to long-term medical costs and mental disability, thereby causing a substantive burden to their families and the society [ 2].
Similar(58)
Chronic disease is a high priority in Australian health policy due to the substantive burden of disease and the associated complexity of health service needs for individuals with diagnosed chronic health complaints12.
For all the probably cosmetic public commitments to growth measures announced in the aftermath of François Hollande's election, this package of rules will almost certainly lead to even higher unemployment, accelerate further deflation and increase the substantive burden of debt.
While some of the above requirements may be covered by an effective agreement, those that are subjective create a substantial burden on a company looking to hire interns to create a substantive program that meets these criteria.
Hence, it appears that while many CRC survivors do well over time, a sizeable subgroup carry a substantive long term health burden.
"The U.S. Supreme Court has said that the burden of proof is a substantive rule," said Howard Jacobs, a lawyer who has represented athletes in previous cases involving the anti-doping agency.
It was noted that a number of high and middle burden provinces had mountainous remote areas where a substantive portion of MARPs and PLHIV had limited physical access to health facilities.
A substantive disagreement.
She declined requests for a substantive interview.
But Robin then adds a substantive component.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com