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The phrase "a substantive breakthrough on" is correct and usable in written English.
It can be used when discussing significant progress or advancements in a particular area or topic.
Example: "The researchers announced a substantive breakthrough on the development of a new vaccine."
Alternatives: "a significant advancement in" or "a major development regarding".
Exact(1)
Few analysts expect a substantive breakthrough on Thursday, but the meeting may clear the way for a resumption of the stalled broader talks.
Similar(59)
Few analysts expect a substantive breakthrough Thursday, but the meeting may clear the way for a resumption of stalled broader talks.
Neither Israeli nor Palestinian officials expressed optimism about prospects for a substantive negotiating breakthrough in the last days of the Clinton presidency.
"I don't expect to see miraculous, substantive breakthroughs," she said.
demonstrate that contemplative practices may have a substantive impact on biological processes critical for physical health...
PtDAs can have a substantive effect on over- and under-use of elective surgeries.
The PAR activities did not have a substantive effect on the gentamicin indicator.
Depression has a substantive negative impact on quality of life.
"This shows the substantive negotiations on China entering the WTO have already been completed". "I can say we have achieved a major breakthrough on the important issues of China's accession," Pierre-Louis Girard, chairman of the WTO working party at negotiations, told reporters in Geneva.
A Breakthrough on the M.T.A.
A breakthrough on borders is still the big hope.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com