The phrase "a substantive barrier" is correct and usable in written English.
It can be used to refer to a significant obstacle or hindrance in a particular context, often in discussions about policy, law, or social issues.
Example: "The new regulations created a substantive barrier to entry for small businesses trying to compete in the market."
Alternatives: "a significant obstacle" or "a major hindrance."
Moreover, haplotype sharing across the river was greater at its mouth than in the headwaters, a pattern opposite that expected if the river were a substantive barrier.
This is a point about terminological clarity, not a substantive barrier to discussing such asymmetric relations.
They reported that a substantive barrier to optimal patient management is the lack of an effective means to monitor CVD progression.
The lack of consensus on what is appropriate methodology remains a substantive barrier to understanding the role of osteopathic medicine in chronic non-specific lower back pain, which forms a major presentation to osteopathic clinical practice.
Fiyaz Mughal, the founder and director of the community cohesion group Faith Matters, welcomed the initiative but said there would be "substantive barriers" to its success.
They concluded that lateral cell-cell junctions did not present substantive barriers to hydrodynamic flow between cells.
Cardiologists observed that the cost of treatment and the impact of formularies and healthcare plans on patient finances represent substantive barriers to optimal patient health outcomes.
In particular, a substantive reduction in capacity associated with anthropogenic barriers can reduce the effective population size and consequently genetic variation within the population.
This paper examines both the potential of and barriers to grid-scale energy storage playing a substantive role in transitioning to an efficient, reliable and cost-effective power system with a high penetration of renewable energy sources.
A substantive disagreement.
She declined requests for a substantive interview.
