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Although the ΔF508 mutation virtually eliminates all functional CFTR protein from human airway epithelial cells, it has a substantially weaker effect on CFTR in other tissues and organisms (Ostedgaard et al., 2007; Luo et al., 2009; van Barneveld et al., 2010).
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Using tumbled sand where the sharp edges have been removed such as with play sand will result in a substantially weaker mortar mix.
Indeed, the plants tend to inhibit each other so planting more heavily than recommended can actually cause a substantially weaker stand.
As shown in Table 1, MMA is a substantially weaker sensitizer than most other methacrylates and acrylates.
While the VCA region is critical for yeast Las17 NPF effects, even dimerized it has substantially weaker NPF effects compared to full-length Las17 (Rodal et al. 2003).
A comparable weaker effect was found for VTV as well.
In comparison, IGF-1b appeared to have a weaker effect.
Reboxetine produced a similar, although weaker effect.
A weaker effect was seen for another DAOA/G72 variant, rs778294 (M19).
TNF-α had a weaker effect on SYN transcription, whereas IL-6 had no effect.
These results suggest that among common variants captured on our genotyping platform, AS3MT SNPs are the major genetic determinants of arsenic methylation capacity in this population and that contributions of other common variants to methylation capacity are substantially weaker than the effects of AS3MT variants.
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