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The phrase "a substantially weaker" is correct and usable in written English.
It can be used to describe something that is significantly less strong or effective compared to another thing.
Example: "The new model is a substantially weaker version of its predecessor, lacking many of the features that made it popular."
Alternatives: "a significantly weaker" or "a markedly weaker".
Exact(14)
Indeed, the plants tend to inhibit each other so planting more heavily than recommended can actually cause a substantially weaker stand.
Many main indexes fell, but a substantially weaker dollar bolstered returns for Americans to gains that were as good or even slightly better than that of the S.& P. The average foreign stock mutual fund gained 5percentt for the quarter.
Using this approach, Buckley (2009) found rather substantial changes in the country-level attitude/achievement relationship, such that a strong linear association became replaced by a substantially weaker nonlinear relationship.
That fact, plus a substantially weaker jobs climate going into the fall even before counting some 60,000 jobs lost so far in the mortgage industry gives the Fed room to act without looking desperate.
As shown in Table 1, MMA is a substantially weaker sensitizer than most other methacrylates and acrylates.
However, loss of NDR1/2 in the intestinal epithelium results in a substantially weaker YAP1-dependent phenotype than ablation of Mst1/2 [ 10] or Sav1, a scaffold protein of the MST1/2 kinase complex [ 11].
Similar(46)
This is attributed to the regional development of a substantially weak shear zone (101 to 103 m thick) along this portion of the plate interface caused by the presence of hydrous minerals such as serpentines and talc (Hirauchi et al. 2010b; Kawano et al. 2011; Hirauchi et al. 2013).
Second, a Senate bill that is substantially weaker than Waxman-Markey will not survive a conference and could be opposed explicitly or implicitly by the White House with the argument that EPA's regulatory cap is a stronger environmental law.
Commerce Secretary Donald L. Evans said the census data looked "backward in time at an economy that was substantially weaker" than it is today.
Relatively comprehensive control programmes can be jeopardized if control operations are substantially weaker in just a small proportion of the overall area (Fig. S2C).
A diphosphorylated peptide incorporating Ser487 located just upstream of Ser491 bound with ∼2- to 3-fold higher affinity, whereas binding to a peptide phosphorylated only at Ser487 was substantially weaker.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com