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The phrase "a substantially transformed" is correct and usable in written English.
It can be used in contexts discussing changes in form, function, or character, often in legal or technical discussions regarding products or materials.
Example: "The raw materials underwent a process that resulted in a substantially transformed product, meeting the new regulatory standards."
Alternatives: "a significantly altered" or "a notably changed".
Exact(2)
The largest possible subsamples lead to three related visions of a substantially transformed electricity system dominated by decentral, small and medium-scale solutions coexisting with some centralized, large-scale infrastructures.
Therefore, with continuous occurrence of mutations and several cascades of evolution, a substantially transformed cell will emerge and expand as a subpopulation.
Similar(58)
The opening of the PAC using a computerised system substantially transformed clinical practices in pre-assessment and following a teething period of approximately a year, the nursing staff were entirely satisfied with the running and work practices at the clinic.
The development and refinement of flight vehicles is a technology that has substantially transformed the modern world.
To quality for this scheme a product must be substantially transformed in the manufacturing process.
Britain's landscapes were substantially transformed as a result of prehistoric agricultural clearance and deforestation.
Since 2005, Schaffner has lived in Tyng's former house, which had been substantially transformed by the architect, a distinctive rarity considering her poignant legacy of unbuilt projects.
(e) A component is considered to be manufactured if there are sufficient activities taking place to advance the value or improve the condition of the subcomponents of that component; that is, if the subcomponents have been substantially transformed or merged into a new and functionally different article.
The use of a computerised system for managing preoperative documentation substantially transformed clinical practices and facilitates communication and information-sharing among the multi-disciplinary team.
According to these two authors, Jesus was substantially transformed, but he was not a ghost.
The last few decades have been characterised by an astonishing advancement of the Internet, which has substantially transformed many aspects of life.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com