The knowledge that MM develops exclusively from a protracted phase of monoclonal gammopathy of undetermined significance provides an opportunity to study tumor evolution in this process.
There's no question that local markets have been ruined by appalling socio-economic experiments in Africa, but it is not the only continent to have lived through a protracted phase of state ownership.
The global financial crisis of 2008 was preceded by a protracted phase of economic expansion coupled with low and stable inflation.
Both these populations were characterized by a protracted phase of calcium dysregulation.
Little is known about mitochondrial function in patients who do survive the acute phase of disease, but fail to wean from mechanical ventilation and enter a protracted phase of critical illness.
Given the strong similarities in phenotype to that of RP patients, these transgenic pigs will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.
In fact, scientists at Russia's prestigious Pulkovo Observatory in St . Petersburghave stated that solar activity is waning to such an extent that the global average yearly temperature will begin to decline into a very cold and protracted climate phase.
Several observations suggest differently: a protracted chronic phase, lack of response to several other treatments, relatively high response rate, sustained long-term improvement, and the rapid deterioration of the headache after the device was switched off or had technical failures.
Moreover, as a consequence of a protracted absorption phase, plasma concentrations at late time points were higher following oral administration than those after intravenous dosing.
CML is a paradigmatic stem cell disorder that begins as a protracted chronic phase, characterized by high leukocyte counts and enlarged spleen and liver.
After a short proinflammatory phase, septic patients enter a stage of protracted immunosuppression, which is an important underlying cause of mortality during the late stage of sepsis.
