The phrase "a substantially negative" is correct and usable in written English.
It can be used to describe something that has a significant negative impact or quality.
Example: "The study revealed a substantially negative effect of the new policy on employee morale."
Alternatives: "a significantly adverse" or "a markedly negative".
The Maine senator added that the bill would have a "substantially negative impact on the number of people covered by insurance".
Notably, changing the temperature and salt conditions when calculating ΔG to better reflect those of the PCR conditions used had a substantially negative impact on predictive performance compared to the standard ΔG°37 in 1 M sodium (Fig. 9 and Supplementary Fig. S10).
Those in the classic car sector say it would have a substantially negative impact.
Along similar lines, we find evidence of a substantially negative effect ofunemployment on the affected individuals' capacity to aspire.
Mr Carney said the Bank had been looking at how banks in the UK would fare if the Chinese economy took a substantially negative turn.
First, we find a substantially negative and statistically significant relationship between holding a temporary contract and the amount of workplace training.
But she added that if the success had changed her in any substantially negative way, Alexander, who she said is "one of the all-time nice guys," wouldn't have stayed around.
A yeast model system studied with a fluorescence imaging probe (71) showed a substantially more negative GSH redox potential (very low free GSSG); the relevance for mammalian cell physiology will need to be addressed.
Indeed, non-invasive measurements in cultured microglia have suggested a true input resistance of ∼8 GΩ (Newell & Schlichter, 2005), which, if appropriate for microglia in slices, would imply a substantially more negative resting potential than we measure and, in the absence of voltage-gated channel activation, an oxidase-induced depolarization of about +240 mV from that resting potential.
Table 5 illustrates that when school quality and studenteffort are strong complements in production (ϱ = 2 in thetable) then the elasticity difference of Δ11 may be substantially positive (as for Δ in themodel with a single subject) and ε ̂ 12 may be substantially negative.
Therefore, the fact that cysteine substitutions do not eliminate channel function is not readily interpretable since the sidechain might be neutral, if the pKa value is little perturbed (nominal pKa ∼8.5 9), or might be substantially negative, if the pKa is shifted to ∼7.5 (aided by a nearby S4Arg) [60].
