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The phrase "a substantially more thorough" is correct and usable in written English.
It can be used when comparing the level of thoroughness between two or more subjects, indicating that one is significantly more detailed than the other.
Example: "The new report provides a substantially more thorough analysis of the data compared to the previous version."
Alternatives: "a significantly more comprehensive" or "a markedly more detailed".
Exact(1)
Ideally, we would be able to compare the working conditions of early childhood teachers among the four cities, but as working and vacation hours vary across cities, such a comparison would require a substantially more thorough investigation.
Similar(59)
A year later, a more thorough study confirmed the risk.
It has become an important tool for a more thorough investigation of obstetric care.
A broader conceptualization would have enabled a more thorough and consistent exploration of these dimensions.
"We have a much more thorough process here of representation...
A questioner can ask for a clearer or more thorough explanation of the first answer.
A robust treatment of global estimates requires a more thorough uncertainty analysis.
This is a target group of calves that warrants a more thorough investigation in further studies.
Give the cage a more thorough clean once a week.
A detailed understanding of this complex system requires a more thorough analysis.
Moreover, a more thorough longitudinal assessment of such a patient would have been ideal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com