The phrase "a substantially more severe" is correct and usable in written English.
It can be used when comparing the severity of two or more situations, indicating that one is significantly worse than the other.
Example: "The new policy has resulted in a substantially more severe impact on employee morale than anticipated."
Alternatives: "considerably more serious" or "significantly harsher".
But the more pressing question is this: Does the federal government really need to come in now and suspend all funding for Grand Island Public Schools so that all of the students in that school system receive a substantially more severe punishment than the one that was not actually meted out to Hunter Spanjer?
In addition, the rTgTauEC x APP/PS1 mice exhibited exacerbated neuritic dystrophies, and importantly, degeneration of tau expressing neurons in the EC, a substantially more severe phenotype than observed in age-matched rTauEC mice.
Furthermore, AtrabD2b and AtrabD2c mutant pollen tubes do not grow apically as well as do wild-type pollen tubes and tend to have swollen tips and a shorter length; this phenotype is substantially more severe in AtrabD2b/2c double mutants.
Consistent with a major signaling defect, functional and biochemical defects exhibited by CD148-deficient platelets were substantially more severe than those observed in platelets from FcR γ-chain heterozygous-deficient mice, which express a similar reduction in the GPVI-FcR γ-chain complex.
The effect was substantially more severe than seen in earlier-stage trials of torcetrapib and more than enough to outweigh the drug's beneficial effects on cholesterol.
This fuzziness in the technological threshold of DSL availability is substantially more severe in other countries, effectively limiting the use of the threshold identification to Germany.
I/St mice developed substantially more severe course of the disease, compared to B6 mice, both in terms of survival time (Fig. 1A, P<0.001, Gohen's criterion for survival curves) and CFU counts (Fig. 1B, P<0.01-0.001 at different time points, ANOVA).
African Americans showed substantially more severe impairment of architecture around facial pores than any other racial group.
No evidence indicates that HAdV-14p1 infection is substantially more severe than that by other HAdV serotypes; however, we propose increased surveillance for this emerging agent in Europe and elsewhere in immunologically naive populations.
