These estimates indicated an increased risk related to substantially lower dose than that suggested by Lamm and colleagues [ 21].
The impact of these mechanisms is especially important in high-throughput screens such as microfluidic research platforms where the volume of media for each cell is reduced and application of the same concentrations as in bulk experiments may result in a substantially lower cellular dose, which would be more quickly depleted.
Interestingly, Gatenby and collaborators show that this approach, at least in a mouse tumor model, provides better survival than the current standard protocols, notably with substantially lower doses of chemo drugs (Gatenby et al. 2009).
Many of these studies reported the anxiolytic effect of risperidone occurred at substantially lower doses than those used in the treatment of psychosis, with a concomitant reduction in the incidence of adverse effects [ 32, 27, 25].
However, BIND Biosciences has shown a significant reduction of lung and tonsillar lesions using the combination of nanoparticles and chemotherapeutic drug with prostate-specific membrane antigen (PSMA) with greater efficacy compared with the drug alone, and at substantially lower doses.
However, this work proves that a debugged dose response (DR) modeling, through explicit algebraic equations, enables two simple options to accurately calculate the CI of substantially lower doses than NOEC.
Our study population, comprising critically ill ARDS patients with concomitant organ failure, required substantially lower doses of (approximately) 0.26 µg/kg/min argatroban to achieve the therapeutic aPTT goal.
Chronic exposure will generally produce adverse health effects at substantially lower doses than acute exposure.
Thus, it was suggested that patients with low TPMT expression should be treated with substantially lower doses of thiopurines.
