Sentence examples for a substantially lower affinity from inspiring English sources
Coro1A has a substantially lower affinity for F-actin than Coro1B, but it was able to compete with Coro1B for binding.
Importantly, in vitro these agents are characterised by potent growth inhibitory activity in moderately and highly docetaxel-resistant cell lines, most probably based upon a substantially lower affinity for ABCB1.
Because free kinesin heads in solution have a high affinity for ADP, whereas MT-bound heads exhibit a substantially lower affinity, the release of mantADP from kinesin heads serves as a proxy for the binding of free heads to MTs (Hackney, 1988, 1994, 2002; Gilbert et al., 1995; Hackney et al., 2003; Clancy et al., 2011).
This may be the reason for different subsequent signal transduction and the substantially lower affinity of VEGF-B compared to VEGF-A, which in turn provides a simple explanation of our observation that iBREC proliferation induced by VEGF-A was not notably affected by equimolar amounts of VEGF-B.
PG-116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, the therapeutic targets, while having substantially lower affinity for MMP-1 and -7, both of which were thought to be implicated in the pathogenesis of musculoskeletal toxicity [ 25].
The alpha-1 isoform has substantially lower affinity (Kd in the μM range) for the specific Na,K-ATPase inhibitor, ouabain, than is required to inhibit the alpha-2 and −3 Na,K-ATPase (Kd in the nM range), consistent with the demonstration that 1 mM ouabain is required to retain sodium in the CP [ 30].
NY18 is an intermediate between SC18 and AV18 since it shows a mixed human/avian receptor binding, albeit at substantially lower affinities than SC18 (for the human receptor) and AV18 (for the avian receptor).
"It is going to be of a substantially lower quality.
Dominican priests might agree, but for a substantially lower fee.
They are getting these results, furthermore, at a substantially lower cost.
Having a substantially lower credit rating than rivals, however, could do much wider damage over time.
