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The phrase "a substantially larger increase" is correct and usable in written English.
It can be used when discussing a significant or considerable rise in a particular metric or value, often in contexts like finance, statistics, or research.
Example: "The company reported a substantially larger increase in profits this quarter compared to the last."
Alternatives: "a significantly greater rise" or "a markedly larger growth".
Exact(5)
If you live on the mid-Atlantic coast of the United States, for example, a given amount of melting in faraway Antarctica will produce a substantially larger increase of sea level than the same amount of melting from nearby Greenland.
The near-doubling of the price of ore purchased from Rio Tinto is a substantially larger increase than that negotiated with Vale, a Brazilian firm whose price agreements typically provide a benchmark for other ore producers.
For example, it faulted the governor for what it described as a greater reliance by the state on backdoor borrowing via the state's public authorities, whose bonding authorization would be increased by $3.3 billion in the next fiscal year, a substantially larger increase than the year before.
For example, there was a substantially larger increase in the risk of elevated SUA for development of type 2 diabetes observed in Western countries (RR 1.27) compared with Asian countries (RR 1.09) and for women (RR 1.28) compared with men (RR 1.09).
In particular if the DLS data was obtained for CPX (Kd ∼15 microM), the DLS data are not particularly compelling as evidence for hetero-oligomerization involving multiple SNARE complexes and complexins, as one would have expected a substantially larger increase in apparent particle radius than observed.
Similar(55)
Women reported substantially larger increase in weekly binge drinking during the summer months than men.
Overall, the monthly variations in self-reported alcohol use were similar for men and women, except that women reported substantially larger increase in weekly binge drinking during the summer months than did men.
Additionally, we observe substantially larger increases in TAG levels as well as differential increases in stress resistance in dFatp het females.
So even if we'd raised the minimum wage to $15 an hour, the top 10percentt would still have emerged from the 2009-2014 period with a substantially larger share of the increase in the nation's income than the bottom 90percentt.
We observed that there were a substantially larger number of nodes exhibiting increased entropy in metastatic breast cancer than nodes exhibiting lower average correlation.
Exascale platforms likely will be characterized by a three to four orders of magnitude increase in concurrency, a substantially larger storage capacity, and a deepening of the storage hierarchy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com