The phrase "a substantially higher dose" is correct and usable in written English.
It can be used in contexts related to medicine, pharmacology, or any situation where dosage levels are being compared.
Example: "The study indicated that patients who received a substantially higher dose of the medication experienced more significant side effects."
Alternatives: "a significantly increased dose" or "a markedly higher dose."
The opening of the ring at C-7 and C-8 is consistent with the reduction of cytotoxic potency; however, such modulation does not account for the tolerability of substantially higher dose levels than with PTX.
CT exposes the patient to a substantially higher radiation dose than radiography, rendering it unsuitable for the often needed repeated examinations of these patients.
CT exposes the patient to a substantially higher radiation dose than chest radiography, rendering it unsuitable for the often needed repeated examinations of these patients.
In order to allow for the possibility of a meaningful signal upon initiation of ATII, we preferentially considered patients with a substantially higher starting dose of norepinephrine (20 to 30 mcg/min, as evidenced in Figure 3).
Substantially higher doses of LM975 can be given clinically without dose limiting toxicity.
Patients with a low probability of severe neutropenia (e.g., <30%) as calculated with the nomogram using the standard dose of irinotecan can tolerate substantially higher doses.
For example, during its development, the anti-psychotic drug aripiprazole had no clinical effectiveness at the feasible dose range identified by PET, but in practice, the drug was found to be effective and safe at substantially higher doses.
For instance, AA individuals who carry genetic variants that reduce vitamin D hydroxylation and binding protein stability may require substantially higher doses of vitamin D supplementation to maintain optimal serum 25(OH D levels.
Given the similar and repetitive structure of the liver parenchyma within and between patients, the detected heterogeneities in normal liver parenchyma can partly explain the survival of normal tissue in regions receiving a substantially higher mean absorbed dose than could be tolerated with more homogeneous dose distributions resulting from external radiation techniques.
