The phrase "a substantially higher affinity" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly when discussing the strength of interactions, such as between molecules or receptors.
Example: "The new compound demonstrated a substantially higher affinity for the target receptor compared to the previous version."
Alternatives: "a significantly greater affinity" or "a markedly higher affinity".
Among the Coro1s, Coro1A bound to platelet actin with the lowest affinity with Kd=2.569 μM, whereas Coro1B displayed a substantially higher affinity with a Kd=0.467 μM.
Thus, hagfish insulin would in fact be predicted to have a substantially higher affinity than human insulin if only the classical binding surface was involved.
The second-generation BAS colesevelam HCl has been shown to bind bile acids in vitro with a substantially higher affinity than either cholestyramine or colestipol.
Murine CD8 binds to murine pMHCI with a substantially higher affinity than the equivalent human interaction 6, such that CD8 might make a more significant contribution to stabilisation of the TCR/pMHCI interaction in this system.
Similarly, the affinity of daidzein for ER-α and ER-β was found to be approximately 20,000- and 500-fold lower than that of E2 (Lehmann et al. 2005) Unlike E2, which binds both ER-α and ER-β with similar affinity, many phytoestrogens display a substantially higher affinity for ER-β.
Therefore, we have evaluated the binding kinetics of two anti-VEGF antibodies, ranibizumab and bevacizumab, and VEGF Trap (also known as aflibercept), a novel type of soluble decoy receptor, with substantially higher affinity than conventional soluble VEGF receptors.
These results are consistent with TIG having substantially higher affinity for the bacterial ribosome, broader spectrum of antimicrobial activity and evasion of classic tetracycline-resistance mechanisms and with MIN being more effective than TC as an anti-inflammatory drug.
LD5 showed substantially higher affinity for IgG-F ab' 2, IgG-F ab' 2A than dIgMeither 4L (B3-B3-B3-B3) or SpandwhIgA creathansynergistic didbleither binding sites to the VH3 and Vk regions of the fragment of antigen binding [8].
We also designed and tested another mutant form of CA04/09 HA involving three mutations to make this interaction network hydrophobic (similar to that in SC18 HA) and showed that this mutant (CA04/09mut2) HA had substantially higher affinity than wild-type HA (Figure S3).
Each of the diacyl compounds binds with substantially higher affinity than monoacyl compounds with the same length of acids attached.
Or a substantially higher fine for littering.
