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Quantification of RES content in both lung tissues and the blood stream at different time-points showed a peak concentration at 5 min and a substantially decreased concentration at 15 min for both compartments (Fig. 1a,b).
A second mutant strain, P. putida Δpgl, that lacked 6-phosphogluconolactonase, exhibited a substantially decreased PHA synthesis, as was also predicted by the model.
Subsequently, a rational design to recombine beneficial substitutions within loops 1 and 4 yielded variant L6 with a substantially decreased S0.5 value (0.17 mM).
Co-immunoprecipitations from tsA-201 cells expressing the GFP-tagged III-IV variants together with mCherry-tagged calnexin C-tail (mCherry-CNXBD) revealed a substantially decreased interaction of the calnexin C-tail with the III-IV variant containing the GAERS mutation (Fig. 5C).
In the first iteration, the proposed DS scheme with M=1 achieves a substantially decreased BER compared to the scheme in [10].
Alongside, a substantially decreased uptake in CXCR4-positive lymphoma xenografts, [68Ga]NOTA-pentixafor also shows enhanced accumulation in the excretory organs, leading to low tumor/background ratios and inferior imaging contrast compared to [68Ga]pentixafor.
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Substitution of T93, which is involved in N-terminal activation, with A substantially decreases the rates of both branched formation and Asn cyclization.
Entering this stressor in Block 2 resulted in a substantially decrease of OR for single mothers' heavy smoking pattern from 2.56 to 2.01, representing a change of 35.3% explained by this stressor.
The Kd of MsbA for binding lipid A was substantially decreased when the daunorubicin binding site was occupied first, and prior binding of nucleotide also modulated lipid A binding affinity.
Replacement of the native formaldehyde oxidation pathway with a functional analog substantially decreased growth in an engineered Methylobacterium, but growth rapidly recovered after six hundred generations of evolution on methanol.
The expression of the fruA and levD operons was at baseline in a levQ mutant and substantially decreased in a levT null mutant, with lower expression with the cognate inducers fructose or mannose, but slightly higher expression in glucose or galactose.
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