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The phrase "a substantial zone of" is correct and usable in written English.
It can be used to describe a significant area or range of something, often in contexts related to geography, science, or abstract concepts.
Example: "The research focused on a substantial zone of biodiversity that had been largely overlooked by previous studies."
Alternatives: "a significant area of" or "a considerable region of".
Exact(2)
Inlet designs can induce non-uniform liquid flow across the separator's cross section with a substantial zone of re-circulation.
Although the injections covered a substantial zone of the targeted cortical area, the tracer was far from filling the entire corresponding cortical area.
Similar(58)
Sixteen of the extracts were selected for use in the 96-well plate assay because they caused substantial zones of inhibition on one or more of the bacteria tested.
There was a substantial spread of zone sizes in comparison to MICs; for example, the majority of S. Typhi isolates (591/1,062 [55.6%]) had an MIC of 8 μg/ml, and the corresponding zone sizes spanned 12 to 27 mm.
With tough adhesives, a substantial process zone develops at the crack tip.
The bus structure reinforced by the composite roll bar was able to secure a substantial margin of the survival zone as well as to meet the requirement specified by ECE R66.
However as we found a substantial number of backcrossed individuals, the hybrid zone could not be very young.
In this paper we describe a substantial extension of Marxan called Marxan with Zones, a decision support tool that provides land-use zoning options in geographical regions for biodiversity conservation.
Roughly two hundred thousand people live in the Ciudad del Este region, including a substantial minority of Arab Muslims; in the Triple Frontier zone, there may be as many as thirty thousand.
Transition zone in the reservoir may hold a substantial portion of oil reserves in place.
The abyssal zone (between 4,000 and 6,000 metres) represents a substantial portion of the oceans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com