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However, there is evidence from TbNMT inhibitors that a substantial window of selectivity can be derived between HsNMT1 and TbNMT despite highly similar active site structures.
A substantial window of opportunity for improvements in functional outcome by G-CSF treatment is also suggested by Lees et al. [ 8], who report effects in rotarod measurements particularly when treatment was delayed to 1 day and longer after MCAO.
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In fact, zVAD-FMK gave an IC50 value of 230 nM in our Fas-assay (data not shown), indicating that there is a substantial window between the anti-apoptotic and T-cell-suppressive activity of caspase inhibitors in general.
Still, there are substantial windows of opportunity for action towards evidence-informed policymaking through the development of new health system strategic plans, and reform initiatives in the region.
Given the promising initial in vitro culture studies of the proteasome inhibitors that revealed a substantial therapeutic window (Table 1), we wanted to assess the effects of these compounds on parasite growth in vivo.
Solid numbers for what the company has referred to as a substantial "reimagining" of Windows as we know it, and the company hopes that same sort of momentum carries over into retail sales.
Low imperfection scores account for a substantial majority of windows for all four sets and the absolute differences between the frequencies at the first few imperfection scores are small.
This represents a substantial time window during which sepsis could potentially be diagnosed and treated earlier.
No substantial window narrowing was observed.
We therefore anticipated a substantial contraction of the flexibility window on inclusion of the ether oSDA in the simulation.
At its earning call last month, Nokia — the only substantial Windows Phone OEM (controlling 90% of the market according to AdDuplex) — revealed it sold a total of just 30 million Lumia devices during in the whole of 2013.
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