The phrase "a substantial underestimate of" is correct and usable in written English.
It can be used when discussing a situation where the actual value or impact of something is significantly lower than what was previously assessed or calculated.
Example: "The report revealed a substantial underestimate of the project's costs, leading to budget overruns."
Alternatives: "a significant underestimation of" or "a considerable miscalculation of".
This discrepancy between the two sets of estimates of the TMRCA likely owes to the inability of the MCA to integrate information from the period of evolution between the two subtypes, leading to a substantial underestimate of the rate of substitution, and consequent underestimation of the date of the TMRCA.
This is according to Russia's official figures, which almost everyone agrees are a substantial underestimate of the true position.
In contrast, the coarse spatial resolution of MODIS-derived products results in a substantial underestimate of change events and thus overestimates forest carbon sinks over the observation period.
And the official figure is believed to be a substantial underestimate of the numbers of youngsters kidnapped and taken to a training camp to become child soldiers.
However, if only 3% of cells die and thus remove their associated propagons from the population, around 200 propagons are lost by 34 hr and this would lead to a substantial underestimate of n0.
While this is likely to be a substantial underestimate of the actual number of fisheries that exist across these regions, these were the fisheries for which we had the necessary information for this mapping exercise.
The numbers of E. helvum we estimate being harvested not only exceeds previous bushmeat reports, but is likely a substantial underestimate; our survey only covered a fraction of the rural areas where most bat hunting occurs (e.g. we visited only 9 out of 163 towns listed on Google Maps for the Volta region).
Elena Naumova, director of the Tufts University Initiative for the Forecasting and Modeling of Infectious Disease, says this is likely a substantial underestimate, because these pathogens are rarely tested for in clinical settings, even in severely ill patients.
However, due to the inherent insensitivity of blood cultures for detecting bacteraemia in children, this might be a substantial underestimate.
Furthermore, 19% of the positively selected streptococci gene clusters encode proteins that are known to have body-site specific expression pattern during invasive disease; a result which we argue is likely a substantial underestimate.
