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The phrase "a substantial turnover" is correct and usable in written English.
It can be used in contexts related to business, finance, or employment to refer to a significant amount of revenue generated or a high rate of employee turnover.
Example: "The company reported a substantial turnover this quarter, indicating strong sales performance."
Alternatives: "a significant turnover" or "a considerable turnover."
Exact(2)
It therefore seems likely that we will see a substantial turnover on the Court over the course of the next decade.
Taking into account a substantial turnover in migrant populations, the denominator could be 500 1,000 inhabitants, and the incidence rate would be 6.2%12.4%%.
Similar(57)
The fossil assemblages from the Busidima Formation show a substantial species turnover.
Nonmetric Multidimensional Scaling (NMS) ordinations and analyses of taxon frequencies reveal a substantial community turnover and corresponding replacement of the dominant basidiomycetes by ascomycetes in the HB treatment.
Lebuhn et al.[ 15] found that qPCR was an acceptable method to estimate bacterial viability in samples having a substantial metabolic turnover (as soil samples) and that DNA from decaying organisms was readily recycled in metabolically active environments.
This is necessary because of the substantial turnover as service members return to civilian life.
The pace has led to substantial turnover in staff at digital news organizations.
There has been substantial turnover; of the 427 staff employed when the prison opened, only 256 are still here.
This weariness no doubt reflects that the 2008 cuts came after the substantial turnover in Mr. Nissinen's early years.
There is still substantial turnover, but the rate fell sharply during the downturn and has yet to recover to the preceding levels.
The evidence we have from places like Milwaukee and Washington, D.C. suggests substantial turnover in voucher programs, with minority students and students with the lowest test scores leaving private schools.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com