The phrase "a substantial target of" is correct and usable in written English.
It can be used when discussing something that is significantly aimed at or affected by a particular action, event, or phenomenon.
Example: "The new policy has become a substantial target of criticism from various advocacy groups."
Alternatives: "a major focus of" or "a significant subject of".
Thus, as previously suggested [42], PKCγ in the dorsal horn could be a substantial target for preventing the development of tactile allodynia in the clinical setting.
Joe Root's inside edge then cannoned into the stumps to give Hasan Ali the first of four wickets and when Morgan drove a full toss gently back to Wasim, England were faltering at 92 for 3. Roy accepted the burden of ensuring a substantial target alongside Stokes, who was initially as wary as an accountant.
Lightning had set a substantial target, thanks primarily to the efforts of Anderson, Tyrone Kane (57) and Dominic Joyce (36).
Although this clinical trial is modest sized, we observed substantial target neutralisation of this biomarker following administration of sifalimumab in blood with a trend in muscle tissue, as well as suppressed signalling activity in several important inflammatory pathways.
However, recent analyses have revealed that PRC1 and PRC2 do not share all their targets: a substantial proportion of PRC2 targets are not occupied by PRC1, and vice versa, which implies that PRC1 and PRC2 can act independently.
The main goal of early phase drug development is the demonstration of substantial target engagement at doses which are safe and tolerable and the determination of a therapeutic dose range.
This indicated that in PXY-positive cells ARF5 antagonizes the effect of overall auxin signalling on a substantial subset of target genes.
With such sputtering techniques a substantial amount of target material can be ionized and used for the engineering of surfaces and coatings.
Even though the exact number of co-regulated genes could not be determined, our data indicate that a substantial fraction of target genes is regulated by individual CNOT proteins.
A substantial portion of target genes (37.4%) had never been observed or predicted as CREB-bound in previous genome-wide studies.
