The phrase "a substantial target" is correct and usable in written English.
It can be used when referring to a significant or considerable goal, objective, or aim in various contexts, such as business, project planning, or strategic discussions.
Example: "Our team has set a substantial target for this quarter, aiming to increase sales by 20%."
Alternatives: "a significant goal" or "a considerable objective."
Soon Mohammad Hafeez was driving Rashid into the stands at long-on and a substantial target seemed on the horizon.
Joe Root's inside edge then cannoned into the stumps to give Hasan Ali the first of four wickets and when Morgan drove a full toss gently back to Wasim, England were faltering at 92 for 3. Roy accepted the burden of ensuring a substantial target alongside Stokes, who was initially as wary as an accountant.
Thus, as previously suggested [42], PKCγ in the dorsal horn could be a substantial target for preventing the development of tactile allodynia in the clinical setting.
These data indicated that noradrenalin neuron was a substantial target of icv nesfatin-1 in the NTS.
Consequently, the energy embedded in wasted food represents a substantial target for decreasing energy consumption in the U.S. A decrease in food waste must be accompanied with a retooling of the food supply chain to ensure that the energy consumed during food production does in fact decrease with a decrease in food waste.
A few patients dosed with placebo also showed MMT8 improvement of 15% or greater at day 98, although no appreciable modulation of the IFNGS was observed in these patients and they did not demonstrate a substantial target modulation difference between 15% or greater MMT8 improvers and less than 15% MMT8 improvers.
Towards the design of new class of podophyllotoxin to target topoisomerase II and tubulin as substantial target in cancer therapy, a series of isoxazolidine podophyllotoxin derivatives were designed.
In this report we present a DNA damage-induced mutagenesis screen with a substantial mutational target size [45], [46].
The main goal of early phase drug development is the demonstration of substantial target engagement at doses which are safe and tolerable and the determination of a therapeutic dose range.
Although this clinical trial is modest sized, we observed substantial target neutralisation of this biomarker following administration of sifalimumab in blood with a trend in muscle tissue, as well as suppressed signalling activity in several important inflammatory pathways.
A device found in north Belfast on 1 May was a substantial bomb targeting police officers, the PSNI said.
