Our findings suggest that ivacaftor treatment led to significant improvements that were substantial, sustained over 48 weeks, and spanned a wide range of symptoms, functioning, and well-being in patients with the G551D-CFTR mutation in the STRIVE study.
To date the only treatment leading to substantial, sustained body weight loss is bariatric surgery.
Mn2+ quenching of the Ca2+ indicator dye revealed substantial sustained divalent cation influx into the hyperpolarized cone IS.
Plasmalemmal EYFP fluorescence formation was observed even though full-length STIM1 EYFP did not reveal substantial sustained puncta formation under these conditions (results not shown) suggesting that an increase in cytosolic Ca2+ from intracellular stores modulates the interaction between STIM1-CT and Golli-BG21.
The news that the men of the Ninth were also sustained by a substantial support facility will do little to re-establish their former reputation as crack killer troops.
"What the record demonstrates is a substantial and sustained commitment to combatting terrorism," said Joel Kaplan, deputy director of the Office of Management and Budget.
Within the cull areas, there was a substantial and sustained reduction in the incidence of disease on cattle farms, which lasted for some years longer than the culling programme itself.
The latter developed a Global Malaria Action Plan GMAPP) for a substantial and sustained reduction of the malaria burden in the near and mid-term, and when new tools would make it possible, the eventual global eradication in the long term (http://www.rollbackmalaria.org/gmap/).org/gmap/
Treatment with GLP-1R agonists in monotherapy or in combination has been associated with a substantial, progressive, sustained, and dose-dependent decrease in body weight (46, 47, 49).
We concluded that the Cardiff Violence Prevention Programme is associated with a substantial and sustained reduction in violence related harm, whether recorded by health services or by the police.
