The phrase "a substantial suppression of" is correct and usable in written English.
It can be used in contexts discussing the reduction or limitation of something significant, such as rights, freedoms, or data.
Example: "The new policy resulted in a substantial suppression of free speech among the citizens."
Alternatives: "a significant curtailment of" or "a considerable restriction on".
Data from mass transients show that the deliberate formation of poisons prior to addition of Pb2+ ions to the electrolyte results in a substantial suppression of upd coverage especially between −0.1 and 0.1 V (sce).
The results obtained show that the present wire device effectively breaks the shock-cell structure, reduces the shock strength, and consequently leads to a substantial suppression of supersonic jet noise.
The obtained results for point and cross mobilities show a substantial suppression of resonant peaks (up to 17 dB), in comparison with the cases of a plate with an uncovered hole of the same power-law profile and of a reference circular plate of constant thickness covered or uncovered by a thin absorbing layer.
We first confirmed that both phosphorylated and unphosphorylated Akt proteins were considerably decreased in cultured Akt1-/ osteoblasts without compensatory increase of Akt2 protein, indicating a substantial suppression of the total Akt signaling by depletion of an isoform Akt1 in osteoblasts (Fig 2A).
The expression of the plasmids encoding these molecules in the HCV replicon and HCVcc-infected cells resulted in a substantial suppression of HCV propagation, suggesting the possibility that these or other similar molecules could be used therapeutically to eliminate HCV from hepatocytes infected with HCV.
Furthermore, the majority of chemotherapeutics does not lead to a substantial suppression of T-cell function.
Replacement of Na+o with equimolar choline reversibly abolished this inward current, and the current required a high concentration (10 µM) of TTX for a substantial suppression (Fig. 6D, n = 6).
In summary, these experiments indicate that a transient and substantial suppression of cbfa1 in C3H10T1/2 cells, grown in the presence of BMP-2, is sufficient to delay mineralization, while not reducing their ability to differentiate towards functional chondrocytes.
Also, electroporation of DC with even higher amounts of truncated Vpr RNA (1 µg per million of DC) did not result in substantial suppression of IL-12 secretion.
Substantial suppression of MAPK activity in MEK-AA-expressing MII eggs but not uninjected or MEK-EE-injected controls was confirmed by MBP kinase assay (Figure 2A).
